I have found developing a new venture can actually be made EASIER by adopting the DevOps philosophy and practices. After all, a small (1-2) person company does not have the resources (or luxury) to hire a developer, QA, operations and even customer service.
So almost by necessity the early players will have to cover multiple roles, development and operations (features and releases) can be mapped directly to a "DevOps" styled business.
That what I did with my previous micro-agency, we eventually became to2 full time people with(I mostly developer, my partner primarily ops backgrounds, but we started cross pollenating to hybrid ourselves :) and 3-4 regular contractors that would be called in as needed. Eventually we started also ongoing managing (operating) some projects for clients (inin addition to adding features).
Though we did not use the term "DevOps" (I did not knowdon't think I knew it existed at the time), we were focused on improving feature to deployment timeframe, and making the client experience as painless as possible.
Also, a DevOps model may make it easier for people to take time off, since their role can be covered by somebody else!
I am just now starting a venture (providing DevOps services) to small business.
So in a nutshell, I think it is not only do I think it is possiblepossible, but I believe it is the BESTBEST way to start!
Good Luck!