In short, you cannot prevent your customers from modifying containers they run in their own infrastructure. Containers are not like binaries that can be obfuscated; they are runtime environments. The code you distribute inside the container, however, can be obfuscated.
Your question alludes to a third-party support issue: clients modifying software they run in their own environments. If you provide tools to operate the containers you supply (e.g. monitoring and logging) then the clients should agree (as part of a software license) not to make unauthorized modifications to them. This applies to all types of third-party software, not just containers.
Depending on your situation, you may also have the option to provide your app as Software As A Service (SaaS) running in a cloud infrastructure.
If your client requires your containers be run on their infrastructure, and refuses to abide by modification restrictions, then you probably don't want to try to support their use of your software.