I think the answer should be yes to ecdsa but no to ed25519, but that it is currently no to both.
You can externally generate an ecdsa keypair and load it into ssh/config/ca but vault-1.4.3 cannot sign using it. I haven't tried ed25519.
Golang's ssh code (which vault uses) doesn't appear to know how to sign with ed25519 but should be able to sign with ecdsa. However, I think there's an issue with an inappropriate default being set elsewhere that means it is always being told to use an rsa-based signing algorithm and hence doomed to fail for ecdsa keys. See:
If I am right, it looks like an easy fix so it may be available soon.